汪秀星 教授，理学博士，博士生导师
科学研究方向 胶质瘤干细胞微环境异质性在胶质瘤干细胞微环境构建，维持及其在肿瘤演进中的功能
联系方式
通讯：江苏省南京市江宁区龙眠大道101号学海楼，邮编211166
电话：025-86869340
电邮：xiuxingwang@njmu.edu.cn
简介
汪秀星，博士，教授，博士生导师，入选国家级高层次青年人才，江苏省特聘教授。437ccm必赢国际细胞生物学系/国家卫生健康委员会抗体技术重点实验室教授。 现为中国神经科学学会神经肿瘤分会常务理事、中国细胞生物学会医学细胞生物学分会委员、中国医师协会脑胶质瘤专业委员会基础与转化委员、江苏省细胞与发育生物学会理事。以通讯作者和第一作者在Cancer Discovery (2021), Cell Stem Cell (2018), Nature Neuroscience (2017), Science Translational Medicine (2019), JEM (2013, 2019), Cancer Research (2017)等杂志上发表论文。同时，以共同作者的在Nature, Cell , Nature Medicine, Cell Stem Cell, Cancer Discovery, Nature Cancer, Science Translational Medicine, JCI,JEM等杂志上发表论文。目前实验室主要聚焦于从分子，细胞，动物，病人层面深入研究胶质瘤干细胞代谢微环境和免疫微环境，并探讨其功能及其调节机制。阐释清楚胶质瘤干细胞代谢微环境和免疫微环境的调控机制，有针对性地开展针对GSCs靶向精准治疗研究，来探究精准治疗在GBM治疗中的意义。
教育背景及工作经历
1998.09-2002.07 安徽科技学院 动物科学系 本科
2005.09-2008.07 南京农业大学动物科技学院 硕士
2008.09-2013.08 南京大学模式动物研究所 博士
2014.11-2017.07 美国克利夫兰医学中心Lerner研究所 博士后
2017.08-2018.09 美国加州大学圣地亚哥分校医学系 博士后
2018.10-2019.06 美国加州大学圣地亚哥分校医学系 助理项目科学家
2019.9-至今 437ccm必赢国际细胞生物学系 教授，博士生导师
学术兼职
中国神经科学学会神经肿瘤分会常务委员
中国细胞生物学会医学细胞生物学会委员
中国医师协会脑胶质瘤专业委员会基础与转化委员
江苏省细胞与发育生物学会理事
奖项及荣誉
2020 “国家级高层次青年人才”
2019 “江苏省特聘教授
承担科研课题
1. 肿瘤干细胞微环境 “国家级高层次青年人才” 2020-2023 主持
2. 肿瘤干细胞微环境 “江苏省特聘教授” 2020-2023 主持
3. CXCL8和C1ORF61对胶质母细胞瘤异质性调控机制及联合靶向治疗的研究 81570499 国家自然基金面上项目 2021-2024 主持
近五年代表性论文、专利
1. Deobrat Dixit, Briana C. Prager, Ryan C. Gimple, Qiulian Wu, Yang Wang, Reilly L. Kidwell, Hui Xian Poh, Leo J. Y. Kim, Zhixin Qiu, Qi Xie, Kristoffer Vitting-Seerup,, Shruti Bhargava, Zhen Dong, Li Jiang, Zhe Zhu, Petra Hamerlik, Samie R. Jaffrey, Crystal Zhao*, Xiuxing Wang*, Jeremy N. Rich*.The RNA m6A reader YTHDF2 maintains oncogenes expression and is a targetable dependency in glioblastoma stem cells (Co-corresponding author, Cancer Discovery, 2021)
2. Xiuxing Wang, Briana C. Prager , Qiulian Wu, Leo J. Y. Kim, Ryan C. Gimple, Yu Shi, Kailin Yang, Andrew Morton, Wenchao Zhou, Zhe Zhu, Elisabeth Anne Adanma Obara, Tyler E. Miller, Anne Song, Sisi Lai, Christopher G. Hubert, Xun Jin, Zhi Huang, Xiaoguang Fang, Deobrat Dixit, Weiwei Tao, Kui Zhai, Cong Chen, Zhen Dong, Guoxin Zhang, Stephen M. Dombrowski, Petra Hamerlik, Stephen C. Mack, Shideng Bao, Jeremy N. Rich: Reciprocal signaling between Glioblastoma Stem Cells and Differentiated Tumor Cells Promotes Malignant Progression. Cell Stem Cell 04/2018; 22(4).
3. Xiuxing Wang#, Kailin Yang#, Qi Xie, Qiulian Wu, Stephen C Mack, Yu Shi, Leo J Y Kim, Briana C Prager, William A Flavahan, Xiaojing Liu, Meromit Singer, Christopher G Hubert, Tyler E Miller, Wenchao Zhou, Zhi Huang, Xiaoguang Fang, Aviv Regev, Mario L Suv, Tae Hyun Hwang, Jason W Locasale, Shideng Bao, Jeremy N Rich*. Purine synthesis promotes maintenance of brain tumor initiating cells in glioma. Nature Neuroscience 03/2017; 20(5).
4. Xiuxing Wang#, Kailin Yang#, Qiulian Wu, Leo J.Y. Kim, Andrew R. Morton, Ryan C. Gimple, Briana C. Prager, Yu Shi, Wenchao Zhou, Shruti Bhargava, Zhe Zhu, Li Jiang, Weiwei Tao, Zhixin Qiu, Linjie Zhao, Guoxing Zhang, Xiqing Li, Sameer Agnihotri, Paul S. Mischel, Stephen C. Mack, Shideng Bao, Jeremy N. Rich*. Targeting Pyrimidine Synthesis Accentuates Molecular Therapy Response in Glioblastoma Stem Cells. Science Translational Medicine, 08/2019 (Cover Story)
5. Xiuxing Wang, zhi huang, Qiulian Wu, Briana C Prager, Stephen C Mack, Kailin Yang, Leo J. Y. Kim, Ryan C Gimple, Yu Shi, Sisi Lai, Qi Xie, Tyler E. Miller, Christopher G Hubert, Anne Song, Zhen Dong, Wenchao Zhou, Xiaoguang Fang, Zhe Zhu, Vaidehi Mahadev, Shideng Bao, Jeremy N. Rich* MYC-Regulated Mevalonate Metabolism Maintains Brain Tumor-Initiating Cells. Cancer Research 07/2017; 77(18).
6. Stephen C. Mack#, Irtisha Singh#, Xiuxing Wang#, Rachel Hirsch, Quilian Wu, Jean A.Bernatchez, Zhe Zhu, Ryan C. Gimple, Leo J.Y. Kim, Andrew Morton, Sisi Lai, Zhixin Qiu, Rosie Villagomez, Briana C. Prager, Kelsey C. Bertrand, Clarence Mah, Wenchao Zhou, Christine Lee, Gene H. Barnett, Michael A. Vogelbaum, Andrew E. Sloan, Lukas Chavez, Shideng Bao, Peter C. Scacheri, Jair L. Siqueira-Neto, Charles Y. Lin2*, Jeremy N. Rich*. CHROMATIN LANDSCAPES REVEAL DEVELOPMENTALLY ENCODED TRANSCRIPTIONAL STATES THAT DEFINE GLIOBLASTOMA. (Journal of Experimental Medicine, 04/2019. Co-first author)
7. Zhixin Qiu, Linjie Zhao, Jia Z Shen, Zhengyu Liang, Qiulian Wu, Kailin Yang, Lihua Min, Ryan C Gimple, Qiyuan Yang, Shruti Bhargava, Chunyu Jin, Cheryl Kim, Denise Hinz, Deobrat Dixit, Jean A Bernatchez, Briana C Prager, Guoxin Zhang, Zhen Dong, Deguan Lv, Xujun Wang, Leo JY Kim, Zhe Zhu, Katherine A Jones, Ye Zheng, Xiuxing Wang, Jair L Siqueira-Neto, Lukas Chavez, Xiang-Dong Fu, Charles Spruck, Jeremy N Rich.Transcription Elongation Machinery Is a Druggable Dependency and Potentiates Immunotherapy in Glioblastoma Stem Cells. Cancer Discovery 1/2021.
8. Deobrat Dixit, Briana C Prager, Ryan C Gimple, Tyler E Miller, Qiulian Wu, Shira Yomtoubian, Reilly L Kidwell, Deguan Lv, Linjie Zhao, Zhixin Qiu, Guoxin Zhang, Derrick Lee, Donglim Esther Park, Robert J Wechsler-Reya, Xiuxing Wang, Shideng Bao, Jeremy N Rich. Glioblastoma stem cells reprogram chromatin in vivo to generate selective therapeutic dependencies on DPY30 and phosphodiesterases. Science Translational Medicine 1/2022 14(626).
9. Guoxin Zhang, Zhen Dong, Ryan C Gimple, Arthur Wolin, Qiulian Wu, Zhixin Qiu, Lisa M Wood, Jia Z Shen, Li Jiang, Linjie Zhao, Deguan Lv, Briana C Prager, Leo JY Kim, Xiuxing Wang, Lingdi Zhang, Ryan L Anderson, Jeffrey K Moore, Shideng Bao, Thomas H Keller, Grace Lin, Congbao Kang, Petra Hamerlik, Rui Zhao, Heide L Ford, Jeremy N Rich. Targeting EYA2 tyrosine phosphatase activity in glioblastoma stem cells induces mitotic catastrophe. Journal of Experimental Medicine. 10/2021. 218(11).
10. Weiwei Tao, Aili Zhang, Kui Zhai, Zhi Huang, Haidong Huang, Wenchao Zhou, Qian Huang, Xiaoguang Fang, Briana C Prager, Xiuxing Wang, Qiulian Wu, Andrew E Sloan, Manmeet S Ahluwalia, Justin D Lathia, Jennifer S Yu, Jeremy N Rich, Shideng Bao. SATB2 drives glioblastoma growth by recruiting CBP to promote FOXM1 expression in glioma stem cells. EMBO molecular medicine. 12/2020. 12(12).
11. Briana C Prager, Harish N Vasudevan, Deobrat Dixit, Jean A Bernatchez, Qiulian Wu, Lisa C Wallace, Shruti Bhargava, Derrick Lee, Bradley H King, Andrew R Morton, Ryan C Gimple, Melike Pekmezci, Zhe Zhu, Jair L Siqueira-Neto, Xiuxing Wang, Qi Xie, Clark Chen, Gene H Barnett, Michael A Vogelbaum, Stephen C Mack, Lukas Chavez, Arie Perry, David R Raleigh, Jeremy N Rich. The meningioma enhancer landscape delineates novel subgroups and drives druggable dependencies. Cancer discovery, 11/2020, 10(11)
12. Ryan Gimple, Xiuxing Wang* RAS: Striking at the Core of the Oncogenic Circuitry. Frontiers in Oncology, 08/2019.
13. Andrew R. Morton, Nergiz Dogan-Artun, Zachary J. Faber, Graham MacLeod, Cynthia F. Bartels, Megan S. Piazza, Kevin C. Allan, Stephen C. Mack, Xiuxing Wang, Ryan C. Gimple, Qiulian Wu, Brian P. Rubin, Shashirekha Shetty, Stephane Angers, Peter B. Dirks, Richard C. Sallari, Mathieu Lupien, Jeremy N. Rich,* and Peter C. Scacheri* Functional Enhancers Shape Extrachromosomal Oncogene Amplifications. Cell, 11/2019.
14. Stephen C. Mack, Kristian W. Pajtler, Lukas Chavez, Konstantin Okonechnikov, Kelsey C. Bertrand, Xiuxing Wang, Serap Erkek, Alexander Federation, Anne Song, Christine Lee, Xin Wang, Laura McDonald, James J. Morrow, Alina Saiakhova, Patrick Sin-Chan, Qiulian Wu, Kulandaimanuvel Antony Michaelraj, Tyler E. Miller, Christopher G. Hubert, Marina Ryzhova, Livia Garzia, Laura Donovan, Stephen Dombrowski, Daniel C. Factor, Betty Luu, Claudia L. L. Valentim, Ryan C. Gimple, Andrew Morton, Leo Kim, Briana C. Prager, John J. Y. Lee, Xiaochong Wu, Jennifer Zuccaro, Yuan Thompson, Borja L. Holgado, Jüri Reimand, Susan Q. Ke, Adam Tropper, Sisi Lai, Senthuran Vijayarajah, Sylvia Doan, Vaidehi Mahadev, Ana Fernandez Miñan, Susanne N. Gröbner, Matthias Lienhard, Marc Zapatka, Zhiqin Huang, Kenneth D. Aldape, Angel M. Carcaboso, Peter J. Houghton, Stephen T. Keir, Till Milde, Hendrik Witt, Yan Li, Chao-Jun Li, Xiu-Wu Bian, David T. W. Jones, Ian Scott, Sheila K. Singh, Annie Huang, Peter B. Dirks, Eric Bouffet, James E. Bradner, Vijay Ramaswamy, Nada Jabado, James T. Rutka, Paul A. Northcott, Mathieu Lupien, Peter Lichter, Andrey Korshunov, Peter C. Scacheri, Stefan M. Pfister, Marcel Kool*, Michael D. Taylor*, Jeremy N. Rich* Therapeutic targeting of ependymoma as informed by oncogenic enhancer profiling. Nature 12/2017; 553(7686).
15. Brian J Golbourn, Matthew E Halbert, Katharine Halligan, Srinidhi Varadharajan, Brian Krug, Nneka E Mbah, Nisha Kabir, Ann-Catherine J Stanton, Abigail L Locke, Stephanie M Casillo, Yanhua Zhao, Lauren M Sanders, Allison Cheney, Steven J Mullett, Apeng Chen, Michelle Wassell, Anthony Andren, Jennifer Perez, Esther P Jane, Daniel R David Premkumar, Robert F Koncar, Shideh Mirhadi, Lauren H McCarl, Yue-Fang Chang, Yijen L Wu, Taylor A Gatesman, Andrea F Cruz, Michal Zapotocky, Baoli Hu, Gary Kohanbash, Xiuxing Wang, Alenoush Vartanian, Michael F Moran, Frank Lieberman, Nduka M Amankulor, Stacy G Wendell, Olena M Vaske, Ashok Panigrahy, James Felker, Kelsey C Bertrand, Claudia L Kleinman, Jeremy N Rich, Robert M Friedlander, Alberto Broniscer, Costas Lyssiotis, Nada Jabado, Ian F Pollack, Stephen C Mack, Sameer Agnihotri. Loss of MAT2A compromises methionine metabolism and represents a vulnerability in H3K27M mutant glioma by modulating the epigenome. Nature Cancer 04/2022.
16. Jin-Zhu Wang, Hong Zhu, Pu You, Hui Liu, Wei-Kang Wang, Xiaojuan Fan, Yun Yang, Keren Xu, Yingfeng Zhu, Qunyi Li, Ping Wu, Chao Peng, Catherine CL Wong, Kaicheng Li, Yufeng Shi, Nu Zhang, Xiuxing Wang, Rong Zeng, Ying Huang, Liusong Yang, Zefeng Wang, Jingyi Hui. Up-regulated YB-1 protein promotes glioblastoma growth through an YB-1/CCT4/mLST8/mTOR pathway. JCI. 03/2022
17. Xiu-Xing Wang, Pu Ying, Fan Diao, Qiang Wang, Dan Ye, Chen Jiang, Ning Shen, Na Xu, Wei-Bo Chen, Shan-Shan Lai, Shan Jiang, Xiao-Li Miao, Jin Feng, Wei-Wei Tao, Ning-Wei Zhao, Bing Yao, Zhi-Peng Xu, Hai-Xiang Sun, Jian-Min Li, Jia-Hao Sha, Xing-Xu Huang, Qing-Hua Shi, Hong Tang, Xiang Gao, Chao-Jun Li. Altered protein prenylation in Sertoli cells is associated with adult infertility resulting from childhood mumps infection. JEM. 07/2013
18. Xun Jin, Leo J Y Kim, Qiulian Wu, Lisa C Wallace, Briana C Prager, Tanwarat Sanvoranart, Ryan C Gimple, Xiuxing Wang, Stephen C Mack, Tyler E Miller, Ping Huang, Claudia L Valentim, Qi-gang Zhou, Jill S Barnholtz-Sloan, Shideng Bao, Andrew E Sloan, Jeremy N Rich*. Targeting glioma stem cells through combined BMI1 and EZH2 inhibition. Nature Medicine 10/2017; 23(11).
19. Zhe Zhu, Pinar Mesci, Jean A.Bernatchez, Ryan C.Gimple, Xiuxing Wang, Simon T.Schafer, Hiromi I.Wettersten, Sungjun Beck, Alex E.Clark, Qiulian Wu, Briana C. Prager, Leo J.Y. Kim, Rekha Dhanwani, Sonia Sharma, Alexandra Garancher, Sara M.Weis, Stephen C.Mack, Priscilla D.Negraes, Cleber A.Trujillo, Luiz O.Penalva, Jing Feng, Zhou Lan, Rong Zhang, Alex W.Wessel, Sanjay Dhawan, Michael S.Diamond, Clark C.Chen, Robert J.Wechsler-Reya, Fred H.Gage, Hongzhen Hu, Jair L.Siqueira-Neto, Alysson R.Muotri, David A.Cheresh, Jeremy N.Rich. Zika Virus Targets Glioblastoma Stem Cells through a SOX2-Integrin αvβ5 Axis. Cell Stem Cell 02/2020; 26(2), 187-204.
20. Yu Shi, Olga A Guryanova, Wenchao Zhou, Chong Liu, Zhi Huang, Xiaoguang Fang, Xiuxing Wang, Cong Chen, Qiulian Wu, Zhicheng He, Wei Wang, Wei Zhang, Tao Jiang, Qing Liu, Yaping Chen, Wenying Wang, Jingjing Wu, Leo Kim, Ryan C Gimple, Hua Feng, Hsiang-Fu Kung, S Yu Jennifer, Jeremy N Rich, Yi-Fang Ping*, Xiu-Wu Bian*, Shideng Bao*. Ibrutinib Targets Glioblastoma Stem Cells by Disrupting BMX-mediated STAT3 Activation to Suppress Malignant Growth and Radioresistance. Science Translational Medicine. 2018.
21. Zhe Zhu, Matthew J. Gorman, Lisa D. McKenzie, Jiani N. Chai, Christopher G. Hubert, Briana C. Prager, Estefania Fernandez, Justin M. Richner, Rong Zhang, Chao Shan, Xiuxing Wang, Pei-Yong Shi, Michael S. Diamond*, Jeremy N. Rich*, Milan G. Chheda*. Zika virus has oncolytic activity against glioblastoma stem cells. Journal of Experimental Medicine 09/2017; 214(9).
22.Ryan C Gimple, Reilly L. Kidwell, Leo Kim, Tengqian Sun, AnthonyD. Gromovsky, Qiulian Wu, Megan Wolf, Deguan Lv, Shruti Bhargava, Li Jiang, Briana C Prager, Xiuxing Wang, Qing Ye, Zhe Zhu, Guoxin Zhang, Zhen Dong, Linjie Zhao, Derrick Lee, Junfeng Bi, Andrew E. Sloan.Paul S. Mischel, Mark Brown, Hu Cang, Tao Huan, Stephen C. Mack, Qi Xie, Jeremy Rich*.Glioma Stem Cell Specific Super Enhancer Promotes Polyunsaturated Fatty Acid Synthesis to Support EGFR Signaling. Cancer Discovery, 06/2019, 0.1158/2159-8290
23. Zhen Dong, Guoxin Zhang, Meng Qu, Ryan C. Gimple, Qiulian Wu, Zhixin Qiu, Briana C. Prager, Xiuxing Wang, Leo J.Y. Kim, Andrew R. Morton, Deobrat Dixit, Wenchao Zhou, Haidong Huang, Bin Li, Zhe Zhu, Shideng Bao, Stephen C. Mack, Lukas Chavez, Steve A. Kay, Jeremy N. Rich. Targeting Glioblastoma Stem Cells through Disruption of the Circadian Clock. Cancer Discovery, 08/2019.
24. Yu Shi, Yi-Fang Ping, Wenchao Zhou, Zhi-Cheng He, Cong Chen, Bai-Shi-Jiao Bian, Lin Zhang, Lu Chen, Xun Lan, Xian-Chao Zhang, Kai Zhou, Qing Liu, Hua Long, Ti-Wei Fu, Xiao-Ning Zhang, Mian-Fu Cao, Zhi Huang, Xiaoguang Fang, Xiuxing Wang, Hua Feng, Xiao-Hong Yao, Shi-Cang Yu, You-Hong Cui, Xia Zhang, Jeremy N. Rich, Shideng Bao*, Xiu-Wu Bian*.Tumour-associated macrophages secrete pleiotrophin to promote PTPRZ1 signalling in glioblastoma stem cells for tumour growth. Nature Communications 06/2017; 8.
25. Weiwei Tao, Chengwei Chu, Wenchao Zhou, Zhi Huang, Kui Zhai, Xiaoguang Fang, Qian Huang, Aili Zhang, Xiuxing Wang, Xingjiang Yu, Haidong Huang, Qiulian Wu, Andrew E. Sloan, Jennifer S. Yu, Xiaoxia Li, George R. Stark, Jeremy N. Rich, Shideng Bao. Dual Role of WISP1 in maintaining glioma stem cells and tumor-supportive macrophages in glioblastoma. Nature Communications, 06/2020, 11.
26. Jinkyu Jung, Leo J.Y. Kim, Xiuxing Wang, Qiulian Wu, Tanwarat Sanvoranart, Christopher G. Hubert, Briana C. Prager, Lisa C. Wallace, Xun Jin, Stephen C. Mack, Jeremy N. Rich*. Nicotinamide metabolism regulates glioblastoma stem cell maintenance. JCI Insight 05/2017; 2(10).
27. Xiaoguang Fang, Wenchao Zhou, Qiulian Wu, Zhi Huang, Yu Shi, Kailin Yang, Cong Chen, Qi Xie, Stephen C. Mack, Xiuxing Wang, Angel M. Carcaboso, Andrew E. Sloan, Gaoliang Ouyang, Roger E. McLendon, Xiu-wu Bian, Jeremy N. Rich, Shideng Bao*. Deubiquitinase USP13 maintains glioblastoma stem cells by antagonizing FBXL14-mediated Myc ubiquitination. Journal of Experimental Medicine 12/2016; 214(1).
28. Qi Xie, Qiulian Wu, Leo Kim, Tyler E. Miller, Brian B. Liau, Stephen C. Mack, Kailin Yang, Daniel C. Factor, Xiaoguang Fang, Zhi Huang, Wenchao Zhou, Kareem Alazem, Xiuxing Wang, Bradley E. Bernstein, Shideng Bao, Jeremy N. Rich*. RBPJ maintains brain tumor–initiating cells through CDK9-mediated transcriptional elongation. Journal of Clinical Investigation 06/2016; 126(7).
29. Chen Jiang, Fan Diao, Yong-Juan Sang, Na Xu, Rui-Lou Zhu, Xiu-Xing Wang, Zhong Chen, Wei-Wei Tao, Bing Yao, Hai-Xiang Sun, Xing-Xu Huang, Bin Xue, Chao-Jun Li: GGPP-Mediated Protein Geranylgeranylation in Oocyte Is Essential for the Establishment of Oocyte-Granulosa Cell Communication and Primary-Secondary Follicle Transition in Mouse Ovary. PLoS Genetics 01/2017; 13(1).
30. Fan Diao, Chen Jiang, Xiu-Xing Wang, Rui-Lou Zhu, Qiang Wang, Bing Yao, Chao-Jun Li: Alteration of protein prenylation promotes spermatogonial differentiation and exhausts spermatogonial stem cells in newborn mice. Scientific Reports 07/2016; 6:28917.
